tlcheng 01
 
Tian-Lu Cheng, PhD

Vice President, Office of Research and Development, Kaohsiung Medical University, Kaohsiung, Taiwan

Chair Professor, Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

Director, Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung, Taiwan

CONTACT

Office of Research and Development
Phone: 886-7-3121101 ext. 2300
Fax: 886-7-3223170

Department of Biomedical Science and Environmental Biology
Phone: 886-7-3121101 ext. 2697
Fax: 886-7-3227508

Address: No.100, Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan

E-mail: tlcheng@kmu.edu.tw, tlcheng5024@gmail.com

EDUCATION

1995/08~1999/07

Ph.D., Graduate Institute of Life Science, Academia Sinica and National Defense Medical Center, Taipei, Taiwan

1991/08~1993/07

M.S., Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan

1987/09~1991/06

B.S., Medical Technology, Kaohsiung Medical College, Kaohsiung, Taiwan

PROFESSIONAL EXPERIENCE

2018/08~

Vice President, Office of Research of Development, Kaohsiung Medical University, Kaohsiung, Taiwan

2018/08~

Chair Professor, Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University, Kaohsiung, Taiwan

2018/08~2018/10

Dean, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan

2015/08~2018/07

Vice Dean, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

2015/08~2018/07

Distinguished Professor, Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University, Kaohsiung, Taiwan

2014/09~2018/07

Director, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

2014/08~

Director, Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung, Taiwan

2013/03~2014/07

Dean, Office for Opereation of Industry-University Cooperation, Kaohsiung Medical University, Kaohsiung, Taiwan

2011/08~20130/02

Chairman, Center for Promotion of Industry-University Cooperation, Kaohsiung Medical University, Kaohsiung, Taiwan

2009/08~2011/07

Chairman, Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University, Kaohsiung, Taiwan

2008/08~2015/07

Professor, Department of Biomedical Science and Environmental Biology , Kaohsiung Medical University, Kaohsiung, Taiwan

2006/08~2009/07

Research-Division Leader, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan

2006/08~2009/07

Division Leader, Biomed-Innovation Incubation Center, Kaohsiung Medical University, Kaohsiung, Taiwan

2005/08~2008/07

Associate Professor, Faculty of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

2002/08~2006//07

Division Leader, MedicoGenomic Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan

2003/08~2004/07

Division Leader, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan

2001/08~2005/07

Assistant Professor, Faculty of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

1999/08~2001/07

Postdoctor, Cancer Group, NHRI

COURSES OFFERED

Immunology, Cancer biology, Biology, Biomedical journal club

SPECIALTY

Humanized Antibody Engineering, Functional Molecular Imaging, Tumor Immunology, Gene Therapy, Functional Genomics, Protein/Antibody Drugs

PUBLICATIONS

2017 Publications

1.  Chang CJ, Chen CH, Chen BM, Su YC, Chen YT, Hershfield MS, Lee MM, Cheng TL, Chen YT, Roffler SR, Wu JY. A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol. Nat Commun. 2017 Sep 12;8(1):522. 2016 IF=12.124 (3/64=4.7%) in MULTIDISCIPLINARY SCIENCES

2.  Chen IJ, Chuang CH, Hsieh YC, Lu YC, Lin WW, Huang CC, Cheng TC, Cheng YA, Cheng KW, Wang YT, Chen FM, Cheng TL*, Tzou SC. Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains. Sci Rep. 2017 Sep 14;7(1):11587. 2016 IF: 4.259 (10/64=15.6%); MULTIDISCIPLINARY SCIENCES

3.  Su YC, Burnouf PA, Chuang KH, Chen BM, Cheng TL*, Roffler SR*. Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy. Nat Commun. 2017 Jun 8;8:15507. doi: 10.1038/ncomms15507. 2016 IF=12.124 (3/64=4.7%) in MULTIDISCIPLINARY SCIENCES

4.  Lin WW, Cheng YA, Kao CH, Roffler SR, Lee YC, Chen BM, Hsieh YC, Chen IJ, Huang BC, Wang YT, Tung YC, Huang MY, Chen FM, Cheng TL*. Enhancement Effect of a Variable Topology of a Membrane-Tethered Anti-Poly(ethylene glycol) Antibody on the Sensitivity for Quantifying PEG and PEGylated Molecules. Anal Chem. 2017 Jun 6;89(11):6082-6090. 2016IF: 6.32 (4/76=5.3%) in CHEMISTRY, ANALYTICAL

5.  Cheng KW, Tseng CH, Yang CN, Tzeng CC, Cheng TC, Leu YL, Chuang YC, Wang JY, Lu YC, Chen YL*, Cheng TL*.Specific Inhibition of Bacterial β-Glucuronidase by Pyrazolo[4,3-c]quinoline Derivatives via a pH-Dependent Manner To Suppress Chemotherapy-Induced Intestinal Toxicity. J Med Chem. 2017 Nov 22;60(22):9222-9238. 2016 IF: 6.259

6.  Chuang, CH; Wu, PC; Tsai, TH; Fang, YP; Tsai, YH; Cheng, TC; Huang, CC; Huang, MY; Chen, FM; Hsieh, YC; Lin, WW; Tsai, MJ*; Cheng, TL*. Development of pH-Sensitive Cationic PEGylated Solid Lipid Nanoparticles for Selective Cancer-Targeted Therapy. J Biomed Nanotechnol. 2017, Volume 13, Number 2, February pp. 192-203(12). 2016 IF: 4.521(7/33=21.2%) in MATERIALS SCIENCE, BIOMATERIALS

7.  Tsai CH, Hsieh PW, Lee YC, Wang CH, Chiu WC, Lu CW, Wang YY, Hu SC, Cheng TL, Yuan SF 3'-Hydroxy-4'-methoxy-β-methyl-β-nitrostyrene inhibits tumor growth through ROS generation and GSH depletion in lung cancer cells. Life Sci. 2017 Mar 1;172:19-262016 IF: 2.936 (45/128=35.2%) in MEDICINE, RESEARCH & EXPERIMENTAL

8.  Ma CJ, Huang CW, Yeh YS, Tsai HL, Hu HM, Wu IC, Cheng TL, Wang JY;  Regorafenib Plus FOLFIRI With Irinotecan Dose Escalated According to Uridine Diphosphate Glucuronosyltransferase 1A1 Genotyping in Patients With Metastatic Colorectal Cancer. Oncol Res. 2017 May 24;25(5):673-679. 2016 IF: 1.74 (169/217=77.9%) in ONCOLOGY

9.  Chang YT, Yeh YS, Ma CJ, Huang CW, Tsai HL, Huang MY, Cheng TL, Wang JY.Optimization of a multigene biochip for detection of relapsed and early relapsed colorectal cancer. J Surg Res. 2017 Dec;220:427-437. 2016 IF=2.187(77/197=39.1%) in SURGERY

2016 Publications

10. Wang YT, Cheng TLRefined models of New Delhi metallo-beta-lactamase-1 with inhibitors: an QM/MM modeling study. J Biomol Struct Dyn. 2016 Oct;34(10):2214-23. 2016 IF=3.123 (25/73=34.2%) in BIOPHYSICS

11. Chang YT, Huang MY, Yeh YS, Huang CW, Tsai HL, Cheng TL, Wang JY. A Prospective Study of Comparing Multi-Gene Biomarker Chip and Serum Carcinoembryonic Antigen in the Postoperative Surveillance for Patients with Stage I-III Colorectal Cancer. PLoS One. 2016 Oct 4;11(10):e0163264 2016 IF=2.806 (15/64=23.4%) in MULTIDISCIPLINARY SCIENCES

12. Lin WW, Hsieh YC, Cheng YA, Chuang KH, Huang CC, Chuang CH, Chen IJ, Cheng KW, Lu YC, Cheng TC, Wang YT, Roffler SR*, Cheng TL*. Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules. Anal Chem. 2016 Dec 20;88(24):12371-12379. 2016 IF: 6.32 (4/76=5.3%) in CHEMISTRY, ANALYTICAL

13. Hsieh YC, Cheng TC, Wang HE, Li JJ, Lin WW, Huang CC, Chuang CH, Wang YT, Wang JY, Roffler SR, Chuang KH, Cheng TL*. Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles. Sci Rep. 2016 Dec 19;6:39119. doi: 10.1038/srep39119.2016 IF: 4.259 (10/64=15.6%); MULTIDISCIPLINARY SCIENCES

14. Hsieh YJ, Tseng SP, Kuo YH, Cheng TL, Chiang CY, Tzeng YM, Tsai WC. Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation. Evid Based Complement Alternat Med. 2016;2016:8680372. 2016 IF=1.74 (10/26=38.5%) in INTEGRATIVE & COMPLEMENTARY MEDICINE

15. Chen BM, Su YC, Chang CJ, Burnouf PA, Chuang KH, Chen CH, Cheng TL, Chen YT, Wu JY, Roffler SR. Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals. Anal Chem. 2016 Nov 1;88(21):10661-10666. 2016 IF: 6.32 (4/76=5.3%) in CHEMISTRY, ANALYTICAL

16. Lin WW, Chen IJ, Cheng TC, Tung YC, Chu PY, Chuang CH, Hsieh YC, Huang CC, Wang YT, Kao CH, Roffler SR,Cheng TL*.A Secondary Antibody-Detecting Molecular Weight Marker with Mouse and Rabbit IgG Fc Linear Epitopes for Western Blot Analysis. PLoS One. 2016 Aug 5;11(8):e0160418. 2016 IF=2.806 (15/64=23.4%) in MULTIDISCIPLINARY SCIENCES

17. Huang WC, Burnouf PA, Su YC, Chen BM, Chuang KH, Lee CW, Wei PK, Cheng TL*, Roffler SR*Engineering Chimeric Receptors To Investigate the Size- and Rigidity-Dependent Interaction of PEGylated Nanoparticles with Cells.ACS Nano. 2016 Jan 26;10(1):648-62.  2016 IF= 13.942 (9/275=3.3 %) in MATERIALS SCIENCE, MULTIDISCIPLINARY

18. Prijovich ZM, Burnouf PA, Chou HC, Huang PT, Chen KC, Cheng TL, Leu YL, Roffler SR. Synthesis and Antitumor Properties of BQC-Glucuronide, a Camptothecin Prodrug for Selective Tumor Activation. Mol Pharm. 2016 Apr 4;13(4):1242-50. 2016 IF= 4.44 (32/257=12.5%) in PHARMACOLOGY & PHARMACY

2015 Publications

19. Huang CC, Kuo KK, Cheng TC, Chuang CH, Kao CH, Hsieh YC, Cheng KH, Wang JY, Cheng CM, Chen CS, Cheng TL*. Development of Membrane-Bound GM-CSF and IL-18 as an Effective Tumor Vaccine. PLoS One. 2015 Jul 17;10(7):2016 IF=2.806 (15/64=23.4%) in MULTIDISCIPLINARY SCIENCES

20. Cheng TC, Pan CH, Chen CS, Chuang KH, Chuang CH, Huang CC, Chu YY, Yang YC, Chu PY, Kao CH, Hsieh YC, Cheng TL*Direct coating of culture medium from cells secreting classical swine fever virus E2 antigen on ELISA plates for detection of E2-specific antibodies. Vet J. 2015 Jul;205(1):107-9. 2016 IF=1.802 (21/136=15.4% in VETERINARY SCIENCES)

21. Tung HY, Su YC, Chen BM, Burnouf PA, Huang WC, Chuang KH, Yan YT, Cheng TL*, Roffler SR. Selective Delivery of PEGylated Compounds to Tumor Cells by Anti-PEG Hybrid Antibodies. Mol Cancer Ther. 2015 Jun;14(6):1317-26. 2016IF=5.764 (36/217=16.6%) in ONCOLOGY

22. Cheng TC, Chuang KH, Roffler SR, Cheng KW, Leu YL, Chuang CH, Huang CC, Kao CH, Hsieh YC, Chang LS, Cheng TL*, Chen CS*. Discovery of specific inhibitors for intestinal E. coli  β-glucuronidase through in silico virtual screening. ScientificWorldJournal.2015;2015:740815. doi: 10.1155/2015/740815. Epub 2015 Mar 9. 2013 IF=1.219(16/55=29.1%) in MULTIDISCIPLINARY SCIENCES

23. Hsieh YT, Chen KC, Cheng CM, Cheng TL, Tao MH, Roffler SR. Impediments to Enhancement of CPT-11 Anticancer Activity by E. coli Directed Beta-Glucuronidase Therapy. PLoS One. 2015 Feb 17;10(2):e0118028. 2016 IF=2.806(15/64=23.4%) in MULTIDISCIPLINARY SCIENCES

24. Changchien JJ, Chen YJ, Huang CH, Cheng TL, Lin SR, Chang LS. Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression.Toxicol Appl Pharmacol. 2015 Apr 1;284(1):33-41 2016 IF=3.791 (15/92=16.3%) in TOXICOLOGY

2014 Publications

25. Wang YTLu CYHour TCCheng TL.Inhibitor and substrate binding by New Delhi metallo-beta-lactamase-1: a molecular dynamics studies.Curr Comput Aided Drug Des. 2014;10(3):197-204. 2016 IF=0.732 (96/105=91.4%) in COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

26. Su YC, Cheng TC, Leu YL, Roffler SR, Wang JY, Chuang CH, Kao CH, Chen KC, Wang HE, Cheng TL*. PET Imaging of β-Glucuronidase Activity by an Activity-Based 124I-Trapping Probe for the Personalized Glucuronide Prodrug Targeted Therapy. Mol Cancer Ther. 2014 Dec;13(12):2852-63. 2016 IF=5.764 (36/217=16.6%) in ONCOLOGY

27. Chien-Han Kao, Jaw-Yuan Wang, Kuo-Hsiang Chuang, Chih-Hung Chuang, Ta-Chun Cheng, Yuan-Chin Hsieh, Yun-long Tseng, Bing-Mae Chen, Steve R. Roffler, Tian-Lu Cheng*. One-step mixing with humanized anti-mPEG bispecific antibody enhances tumor accumulation and therapeutic efficacy of mPEGylated nanoparticles. Biomaterials. 2014 Dec;35(37):9930-40. 2016 IF=8.402 (1/33=3%) in MATERIALS SCIENCE, BIOMATERIALS

28. Kuo-Hsiang Chuang, Chien-Han Kao, Steve R. Roffler, Ssu-Jung Lu, Ta-Chun Cheng, Yun-Ming Wang, Chih-Hung Chuang, Yuan-Chin Hsieh, Yeng-Tseng Wang, Jaw-Yuan Wang, Kuo-Yi Weng and Tian-Lu Cheng*. Development of an Anti-Methoxy Poly(ethylene glycol) (α-mPEG) Cell-Based Capture System to Measure mPEG and mPEGylated Molecules.Macromolecules. 2014, 47, 68806888. 2016 IF=5.835 (5/86=5.8%) in POLYMER SCIENCE

29. Kuo-Hsiang Chuang, Yuan-Chin Hsieh, I-Shiuan Chiang, Chih-Hung Chuang, Chien-Han Kao, Ta-Chun Cheng, Yeng-Tseng Wang, Wen-Wei Lin, Bing-Mae Chen, Steve R. Roffler, Ming-Yii Huang, Tian-Lu Cheng*. High-Throughput Sorting of the Highest Producing Cell via a Transiently Protein-Anchored System. PLoS One. 2014 Jul 18;9(7):e102569. 2016IF=2.806 (15/64=23.4%) in MULTIDISCIPLINARY SCIENCES

30. Cheng CM, Tzou SC, Zhuang YH, Huang CC, Kao CH, Liao KW, Cheng TC, Chuang CH, Hsieh YC, Tai MH, Cheng TL*Functional production of a soluble and secreted single-chain antibody by a bacterial secretion system. PLoS One. 2014 May 13;9(5):e97367. 2016 IF=2.806 (15/64=23.4%) in MULTIDISCIPLINARY SCIENCES

31. Chen YJ, Lin HC, Chen KC, Lin SR, Cheng TL, Chang LS. Taiwan cobra phospholipase A2 suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells. Toxicon. 2014 May 27;86C:79-88. 2016 IF=1.927 (169/257=65.8% in PHARMACOLOGY & PHARMACY)

32. Su YC, Al-Qaisi TS, Tung HY, Cheng TL, Chuang KH, Chen BM, Roffler SR. Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies. MAbs. 2014 May 14;6(4). 2016 IF=4.881(15/128=11.7% in MEDICINE, RESEARCH & EXPERIMENTAL)

33. Chuang CH, Wang WJ, Li CF, Ko CY, Chou YH, Chuu CP, Cheng TL*, Wang JM*. The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer.Cell Death Dis. 2014 May 8;5:e1220. 2016 IF=5.965 (39/190=20.5%) in CELL BIOLOGY

34. Chen YJ, Wu SC, Chen CY, Tzou SC, Cheng TL, Huang YF, Yuan SS, Wang YM. Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection. Biomaterials. 2014 Jan;35(1):304-15. 2016IF=8.402 (1/33=3%) in MATERIALS SCIENCE, BIOMATERIALS

2013 publications

35. Cheng TC, Chuang KH, Chen M, Wang HE, Tzou SC, Su YC, Chuang CH, Kao CH, Chen BM, Chang LS, Roffler SR,Cheng TL*Sensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length. Bioconjug Chem.  2013 Aug 21;24(8):1408-13. 2016 IF=4.818 (10/78=12.8%) in BIOCHEMICAL RESEARCH METHODS

36. Liu WH, Chen YJ, Cheng TL, Lin SR, Chang LS. Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit α and MAPK phosphatase-1 expression in human leukemia U937 cells.Cell Signal. 2013 Sep;25(9):1845-51 2016 IF=3.937 (73/190=38.4%) in CELL BIOLOGY

37. Chen SH, Kuo YT, Cheng TL, Chen CY, Chiu YY, Lai JJ, Chang CC, Jaw TS, Wang YM, Liu GC. In vivo magnetic resonance imaging of mice liver tumors using a new gadolinium-based contrast agent. Kaohsiung J Med Sci. 2013 May;29(5):246-53. 2016 IF=1.15 (103/128=80.5%) in MEDICINE, RESEARCH & EXPERIMENTAL

38. Cheng CM, Chen FM, Lu YL, Tzou SC, Wang JY, Kao CH, Liao KW, Cheng TC, Chuang CH, Chen BM, Roffler S,Cheng TL*Expression of β-glucuronidase on the surface of bacteria enhances activation of glucuronide prodrugs. Cancer Gene Ther. 2013 May;20(5):276-81. 2016 IF=3.652 (40/160=25%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY.

39. Wu SC, Lin KLWang TPTzou SCSingh GChen MHCheng TLChen CYLiu GCLee TWHu SHWang YM.Imaging specificity of MR-optical imaging agents following the masking of surface charge by poly(ethylene glycol).Biomaterials. 2013 May;34(16):4118-27. 2016 IF=8.402 (1/33=3%) in MATERIALS SCIENCE, BIOMATERIALS

40. Lu CY, Tsai HL, Uen YH, Hu HM, Chen CW, Cheng TL, Lin SR, Wang JY. Circulating tumor cells as a surrogate marker for determining clinical outcome to mFOLFOX chemotherapy in patients with stage III colon cancer. Br J Cancer. 2013 Mar 5;108(4):791-7. 2016 IF=6.176 (32/217=14.7%) in ONCOLOGY

2012 publications

41. Chen SHKuo YTSingh GCheng TLSu YZWang TPChiu YYLai JJChang CCJaw TSTzou SCLiu GC,Wang YM. Development of a Gd(III)-Based Receptor-Induced Magnetization Enhancement (RIME) Contrast Agent for β-Glucuronidase Activity Profiling.Inorg Chem. 2012 Nov 1. [Epub ahead of print]2016 IF=4.857 (4/46=8.69%) in CHEMISTRY, INORGANIC & NUCLEAR

42. Lin YJ, Liu YS, Yeh HH, Cheng TL, Wang LF. Self-assembled poly(ε-caprolactone)-g-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells. Int J Nanomedicine. 2012;7:4169-83. 2016 IF=4.3(37/257=14.4%) in PHARMACOLOGY & PHARMACY

43. Chen CH, Liu YK, Lin YL, Chuang HY, Hsu WT, Chiu YH, Cheng TL, Liao KW. A rapid and convenient method to enhance transgenic expression in target cells. Prep Biochem Biotechnol. 2012;42(5):448-61. 2016 IF=1.361 (119/160=74.4%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY

44. Kao CH, Cheng CM, Chuang KH, Chuang CH, Tzou SC, Cheng TC, Hsieh YC, Liao KW, Wang YM, Chang LS, Roffler SR, Chen FM, Cheng TL*. A regularly spaced and self-revealing protein ladder for anti-tag Western blot analysis.Anal Biochem. 2012 Dec 1;431(1):1-3.2016 IF=2.334 (34/76=44.7%) in CHEMISTRY, ANALYTICAL

45. Chen CP, Hsieh YT, Prijovich ZM, Chuang HY, Chen KC, Lu WC, Tseng Q, Leu YL, Cheng TL, Roffler SR. ECSTASY, an adjustable membrane-tethered/soluble protein expression system for the directed evolution of mammalian proteins.Protein Eng Des Sel. 2012 25(7):367-75.2016 IF=2.043 (82/160=51.3%) in Biotechnology & Applied Microbiology

46. Cheng TLChuang KHChen BMRoffler SR. Analytical Measurement of PEGylated Molecules. Bioconjug Chem.2012 May 16;23(5):881-99.2016 IF=4.818 (10/78=12.8%) in BIOCHEMICAL RESEARCH METHODS

47. Ta-Chun Cheng, Steve R. Roffler, Shey-Cherng Tzou, Kuo-Hsiang Chuang, Yu-Cheng Su, Chih-Hung Chuang, Chien-Han Kao, Chien-Shu Chen,I-Hong Harn, Kuan-Yi Liu, Tian-Lu Cheng* and Yu-Ling Leu*.An Activity-Based Infrared Glucuronide Trapping Probe for Imaging b-Glucuronidase Expression in Deep Tissues. J. Am. Chem. Soc. 2012, 134, 31033110. 2016 IF=13.858 (10/166=6%) in CHEMISTRY, MULTIDISCIPLINARY

48. CH Chuang, KH Chuang, HE Wang, SR Roffler, SC Tzou, TC Cheng, CH Kao, SY Wu, WL Tseng, J Shiea, JM Wang*and TL Cheng*. In vivo PET Imaging of protease activity by hydrophilic-to-hydrophobic conversion of a protease substrate.Clin Cancer Res. 2012 Jan 1;18(1):238-247. 2016 IF=9.619 (12/217=5.5%) in ONCOLOGY

49. Chen CHLin YLLiu YKHe PJLin CMChiu YHWu CJCheng TLLiu SJLiao KW. Liposome-based polymer complex as a novel adjuvant: enhancement of specific antibody production and isotype switch. Int J Nanomedicine.2012;7:607-21. Epub 2012 Feb 3. 2016 IF=4.3 (37/257=14.4%) in PHARMACOLOGY & PHARMACY

50. Huang MYWang HMTok TSChang HJChang MSCheng TLWang JYLin SR. EVI2B, ATP2A2, S100B, TM4SF3, and OLFM4 As Potential Prognostic Markers for Postoperative Taiwanese Colorectal Cancer Patients. DNA Cell Biol. 2012 Apr;31(4):625-35. 2016 IF=2.236 (98/167=58.7%) in GENETIC & HEREDITY

2011 publications

51. Kasala D, Lin TS, Chen CY, Liu GC, Kao CL, Cheng TL, Wang YM. [Gd(Try-TTDA)(H2O)]2-: a new MRI contrast agent for copper ion sensing. Dalton Trans. 2011 May 14;40(18):5018-25. 2016 IF=4.029 (7/46=15.2%) in CHEMISTRY, INORGANIC & NUCLEAR

52. Tseng FJ, Liu YK, Chung YS, Lin YL, Chen CH, Wang WY, Chen YC, Tsai NM, Cheng TL, Pan RY, Hu TM, Lee RP, Liao KW A fusion protein composed of receptor binding domain of vascular endothelial growth factor-A and constant region fragment of antibody: angiogenesis antagonistic activity. Cytotechnology. 2011 May;63(3):285-93. 2016 IF=1.857(90/160=56.3%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY

53. Chen KC, Wu SY, Leu YL, Prijovich ZM, Chen BM, Wang HE, Cheng TL, Roffler SR. A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment. Bioconjug Chem. 2011 May 18;22(5):938-48. 2016 IF=4.818 (10/78=12.8%) in BIOCHEMICAL RESEARCH METHODS

54. Huang PT, Chen KC, Prijovich ZM, Cheng TL, Leu YL, Roffler SR. Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of β-glucuronidase in tumors. Cancer Gene Ther. 2011 Jun;18(6):381-9. 2016 IF=3.652(40/160=25%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY.

55. Liu YK, Lin YL, Chen CH, Lin CM, Ma KL, Chou FH, Tsai JS, Lin HY, Chen FR, Cheng TL, Chang CC, Liao KW A unique and potent protein binding nature of liposome containing polyethylenimine and polyethylene glycol: a nondisplaceable property. Biotechnol Bioeng. 2011 Jun;108(6):1318-27 2016 IF=4.481 (23/160=14.4%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY

2010 publications

56. Kuo-Hsiang Chuang, Hsin-Ell Wang, Ta-Chun Cheng, Shey-Cherng Tzou, Chiu-Min Cheng, Chien-Han Kao, Chih-Hung Chuang3, Wei-Lung Tseng, Wen-Chun Hung, Ming-Hong Tai, Tien-Kuei Chang, Bing-Mae Chen, Steve R. Roffler andTian-Lu Cheng*.Development of an Universal Anti-Polyethylene Glycol Reporter Gene for Noninvasive Imaging of PEGylated Probes. Journal of Nuclear Medicine, 2010, 51:933-941 2016 IF: 6.646 (5/127=3.9%) in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

57. Kuo-Hsiang Chuang, Shey-Cherng Tzou, Ya-Chen Chang, Chien-Han Kao, Kuang-Wen, Liao,  Ta-Chun Cheng, Bo-Jyun Huang, Chang-Jer Wu, Wei-Lung Tseng, Jentaie Shiea, Pei-Yu Chu, Steve Roffler, Tian-Lu Cheng* Measurement of Free Polyethylene Glycolby a Novel Cell-Based Anti-Polyethylene Glycol ELISA. Anal Chem. 2010 Mar 15;82(6):2355-62.2016 IF: 6.32 (4/76=5.3%) in CHEMISTRY, ANALYTICAL

58. Kuo-Hsiang Chuang, Hsin-Ell Wang, Fang-Ming Chen, Shey-Cherng Tzou, Chiu-Min Cheng, Ya-Chen Chang, Wei-Lung Tseng, Jentaie Shiea, Shiu-Ru Lin, Jaw-Yuan Wang, Bing-Mae Chen, Steve R. Roffler and Tian-Lu Cheng*. Endocytosis of PEGylated agents enhances cancer imaging and anti-cancer efficacy. Molecular cancer therapeutics, 2010, 9(6);1903-1912 2016 IF=5.764 (36/217=16.6%) in ONCOLOGY

59. Tsao DA, Chang HJ, Lin CY, Hsiung SK, Huang SE, Ho SY, Chang MS, Chiu HH, Chen YF, Tian-Lu Cheng*, Shiu-Ru L. Gene expression profiles for predicting the efficacy of the anticancer drug 5-fluorouracil in breast cancer. DNA Cell Biol. 2010 Jun;29(6):285-93.2016 IF=2.236 (98/167=58.7%) in GENETIC & HEREDITY

60. Su YC, Chen BM, Chuang KH, Tian-Lu Cheng*, Roffler SR. Sensitive Quantification of PEGylated Compounds by Second-Generation Anti-Poly(ethylene glycol) Monoclonal Antibodies. Bioconjug Chem. 2010 Jul 21;21(7):1264-70.2016IF=4.818 (10/78=12.8%) in BIOCHEMICAL RESEARCH METHODS

61. Chung FY, Cheng TL, Chang HJ, Chiu HH, Huang MY, Chang MS, Chen CC, Yang MJ, Wang JY, Lin SR. Differential gene expression profile of MAGE family in taiwanese patients with colorectal cancer. J Surg Oncol. 2010 Aug 1;102(2):148-53.2016 IF=2.993 (43/197=21.8%) in SURGERY

62. Yu CJ, Lin CY, Liu CH, Cheng TL, Tseng WL. Synthesis of poly(diallyldimethylammonium chloride)-coated Fe(3)O(4) nanoparticles for colorimetric sensing of glucose and selective extraction of thiol. Biosens Bioelectron. 2010 Oct 15;26(2):913-7.. 2016 IF=7.78 (2/76=2.6%) in CHEMISTRY, ANALYTICAL

63. Yang Yu Hsiang, Yung-Hsin Wang, Jaw-Yuan Wang, Fang-Ming Chen, Wei-Lung Tseng, Che-Hsin Lin, Ming-Chia Hsieh, Ming-Yii Huang, Shiu-Ru Lin and Tian-Lu Cheng*. Simultaneous detection of multiple single nucleotide polymorphisms by a simple SNP chip. Genet Test Mol Biomarkers. 2010 Oct;14(5):653-9. 2016 IF=1.263 (139/167=83.2%) in GENETICS & HEREDITY

64. Li YC, Chen BM, Wu PC, Cheng TL, Kao LS, Tao MH, Lieber A, Roffler SR. Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling..J Immunol. 2010 Jun 1;184(11):5959-63.2016IF=4.856 (34/151=22.5%) in IMMUNOLOGY

65. Lin CS, He PJ, Tsai NM, Li CH, Yang SC, Hsu WT, Wu MS, Wu CJ, Cheng TL, Liao KW. A potential role for Helicobacter pylori heat shock protein 60 in gastric tumorigenesis.  Biochem Biophys Res Commun. 2010 Feb 5;392(2):183-9.2016 IF=2.466 (38/73=52.1%) in BIOPHYSICS

66. Lin LF, Chuang CH, Li CF, Liao CC, Cheng CP, Cheng TL, Shen MR, Tseng JT, Chang WC, Lee WH, Wang JM. ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. Cancer Res. 2010 Jan 1;70(1):192-201. 2016 IF=9.122 (15/217=6.9%) in ONCOLOGY

2009 publications

67. Shey-Cherng Tzou, Steve Roffler, Kuo-Hsiang Chuang, Hsin-Pei Yeh, Chien-Han Kao, Yu-Cheng Su, Chiu-Min Cheng, Wei-Lung Tseng, Jentaie Shiea, Kai-Wen Cheng, Bing-Mae Chen, Tian-Lu Cheng*and Hsin-Ell Wang. Micro-PET imaging of b-glucuronidase activity by the hydrophobic conversion of a glucuronide probe. Radiology, 2009, Sep;252(3):754-62 2016IF=7.296 (2/127=1.6%) in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

68. Chiu-Min Cheng, Pei-Yu Chu, Kuo-Hsiang Chuang, Steve R. Roffler, Chien-Han Kao, Wei-Lung Tseng, Jentaie Shiea, Wen-Da Chang, Yu-Cheng Su, Bing-Mae Chen, Yun-Ming Wang and Tian-Lu Cheng*. Hapten-derivatized nanoparticle targeting and imaging of gene expression by multimodality imaging systems.Cancer gene therapy, 2009 Jan;16(1):83-90.2016 IF=3.652 (40/160=25%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY

69. Chen YM, Cheng TL, Tseng WL. Fluorescence turn-on detection of iodide, iodate and total iodine using fluorescein-5-isothiocyanate-modified gold nanoparticles. Analyst. 2009 Oct;134(10):2106-12. 2016 IF=3.885 (12/76=15.8%) in CHEMISTRY, ANALYTICAL

70. Li MD, Tseng WL, Cheng TL. Ultrasensitive detection of indoleamines by combination of nanoparticle-based extraction with capillary electrophoresis/laser-induced native fluorescence

71. J Chromatogr A. 2009 Sep 4;1216(36):6451-8. 2016 IF=3.981 (11/76=14.5%) in CHEMISTRY, ANALYTICAL

72. Yu CJ, Cheng TL, Tseng WL. Effects of Mn2+ on oligonucleotide-gold nanoparticle hybrids for colorimetric sensing of Hg2+: improving colorimetric sensitivity and accelerating color change.Biosens Bioelectron. 2009 Sep 15;25(1):204-10. 2016IF=7.78 (2/76=2.6%) in CHEMISTRY, ANALYTICAL

73. Chung FY, Huang MY, Yeh CS, Chang HJ, Cheng TL, Yen LC, Wang JY, Lin SR. GLUT1 gene is a potential hypoxic marker in colorectal cancer patients. BMC Cancer. 2009 Jul 20;9:241. 2016 IF=3.288 (93/217=42.9%) in ONCOLOGY

74. Liu GS, Huang HT, Lin CJ, Shi JY, Liu LF, Tseng RT, Weng WT, Lam HC, Wen ZH, Cheng TL, Hsu KS, Tai MH.Prophylactic Proopiomelanocortin Expression Alleviates Capsaicin-Induced Neurogenic Inflammation in Rat Trachea.Shock. 2009 Dec;32(6):645-50.2016 IF=3.113 (40/197=20.3%) in SURGERY

75. Cheng SC, Cheng TL, Chang HC, Shiea J. Using laser-induced acoustic desorption/electrospray ionization mass spectrometry to characterize small organic and large biological compounds in the solid state and in solution under ambient conditions. Anal Chem. 2009 Feb 1;81(3):868-74. 2016 IF= 6.32 (4/76=5.3%) in CHEMISTRY, ANALYTICAL

76. Li MD, Cheng TL, Tseng WL. Nonionic surfactant-capped gold nanoparticles for selective enrichment of aminothiols prior to CE with UV absorption detection. Electrophoresis. 2009 Jan;30(2):388-95. 2016 IF= 2.744 (24/76=31.6%) in CHEMISTRY, ANALYTICAL

77. Chen TJ, Cheng TH, Chen CY, Hsu SC, Cheng TL, Liu GC, Wang YM. Targeted Herceptin-dextran iron oxide nanoparticles for noninvasive imaging of HER2/neu receptors using MRI. J Biol Inorg Chem. 2009 Feb;14(2):253-60. 2016IF= 2.894 (12/46=26.1%) in CHEMISTRY, INORGANIC & NUCLEAR

2008 Publications

78. Tian-Lu Cheng and Steve Roffler. Membrane-tethered proteins for basic research, imaging and therapy. Medicinal Research Reviews, 2008, Nov;28(6):885-9282016 IF=8.763 (2/60=3.3%) in CHEMISTRY, MEDICINAL

79. Chiu-Min Cheng, Yu-Ling Lu, Kuo-Hsiang Chuang,Wen-Chun Hung, Jentaie Shiea, Yu-Cheng Su, Chien-Han Kao, Bing-Mae Chen, Steve Roffler and Tian-Lu Cheng* Tumor-targeting prodrug-activating bacteria for cancer therapy.Cancer Gene Ther. 2008, Jun;15(6):393-401. 2016 IF=3.652 (40/160=25%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY.

80. Cheng CY, Yuan CH, Cheng SC, Huang MZ, Chang HC, Cheng TL, Yeh CS, Shiea J. Electrospray-assisted laser desorption/ionization mass spectrometry for continuously monitoring the states of ongoing chemical reactions in organic or aqueous solution under ambient conditions. Anal Chem. 2008 Oct 15;80(20):7699-705. 2016 IF= 6.32 (4/76=5.3%) in CHEMISTRY, ANALYTICAL

81. Wu HP, Huang CC, Cheng TL, Tseng WL. Sodium hydroxide as pretreatment and fluorosurfactant-capped gold nanoparticles as sensor for the highly selective detection of cysteine. Talanta. 2008 Jul 15;76(2):347-52. 2016 IF= 4.162(9/76=11.8%) in CHEMISTRY, ANALYTICAL

82. Uen YHLu CYTsai HLYu FJHuang MYCheng TLLin SRWang JY. Persistent Presence of Postoperative Circulating Tumor Cells is a Poor Prognostic Factor for Patients with Stage I-III Colorectal Cancer after Curative Resection. Ann Surg Oncol. 2008, Aug;15(8):2120-8. 2016 IF= 4.041 (17/197=8.6%) in SURGERY

83. Liu FCCheng TLShen CCTseng WLChiang MY. Synthesis of Cysteine-Capped Zn(x)Cd(1)(-)(x)Se alloyed quantum dots emitting in the blue-green spectral range. Langmuir. 2008 Mar 4; 24(5):2162-7. 2016 IF= 3.833(54/275=19.6%) in MATERIALS SCIENCE, MULTIDISCIPLINARY

84. Chen YMYu CJCheng TLTseng WL. Colorimetric detection of lysozyme based on electrostatic interaction with human serum albumin-modified gold nanoparticles. Langmuir. 2008 Apr 1; 24(7):3654-60. 2016 IF= 3.833 (54/275=19.6%) in MATERIALS SCIENCE, MULTIDISCIPLINARY

85. Huang MYWang YHChen FMLee SCFang WYCheng TLHou MFWang JYLin SR. Multiple Genetic Polymorphisms of GSTP1 313AG, MDR1 3435CC, and MTHFR 677CC highly correlated with early relapse of breast cancer patients in Taiwan. Ann Surg Oncol. 2008 Mar;15(3):872-80. 2016 IF= 4.041 (17/197=8.6%) in SURGERY

86. Huang MYFang WYLee SC, Cheng TLWang JYLin SR. ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study. BMC Cancer. 2008 Feb 12;8:50.2016 IF=3.288 (93/217=42.9%) in ONCOLOGY