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行政規劃組組長
 
田育彰 教授
 
電話:2357-20.2322 組長信箱
現任職稱
˙高雄醫學大學醫學影像暨放射科學系 教授
˙高雄醫學大學研發處 行政規劃組組長
˙中山高醫應用科學學分學程 負責人
學歷
˙高雄醫學院 醫技系畢
˙中原大學 醫學工程研究所 碩士
˙中原大學 企業管理研究所 碩士進修
˙Unviersität Heidelberg, Lehrstuhl für Angewandte Physikalische Chemic
    Exchange Program
˙中原大學 醫學工程所 博士
 
經歷
˙University of Texas at Dallas, Department of Chemistry,
     Visiting scholar
˙國立成功大學工業衛生科暨環境醫學研究所蛋白質體核心實驗室
  助理研究員(博士級)
˙The University of North Texas Heath Science Center at Fort
    Worth , Department of Pharmacology & Neuroscience, Visiting
    scholar
˙高雄醫學大學醫學放射技術學系助理教授
˙高雄醫學大學研究資源整合發展中心-功能性蛋白質體研究中
  心 研究顧問
˙高雄醫學大學研究資源整合發展中心發展企劃組 組長
˙編輯委員
1.     Global Journal of Analytical Chemistry
2.     Journal of Chinese Clinical Medicine
3.     Chemical Rapid Communications
4.     The Scientific World Journal (Biomaterials)
5.     Expert, European Commission CORDIS 7th Framework Programme (FP7)
6.     Peer reviewer, Libertas Academica
專長
1.醫學工程 2.蛋白質體學 3.生醫質譜
代表著作
1. M. H. Yang, Y. H. Yang, C. Y. Lu, S. B. Jong, L.J. Chen, Y. F. Lin, S. J. Wu, P. Y. Chu, T. W. Chung, Y. C. Tyan*, “Activity-dependent neuroprotector homeobox protein: a candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease” Journal of Proteomics, 75, 3617-3629, 2012. (SCI, IF=5.074, Rank=10/71, BIOCHEMICAL RESEARCH METHODS )
2. Y. F. Lin, M. H. Yang, Y. H. Yang, W. C. Chen, C. Y. Lu, C. F. Peng, S. B. Jong, L. J. Chen, S. J. Wu, P. Y. Chu, T. W. Chung, Y. C. Tyan*, “Activity-dependent neuroprotector homeobox protein level in Alzheimer's disease in Taiwanese” Genomic Medicine, Biomarkers, and Health Sciences, 4, 48-50, 2012.
3. Y. H. Yang, C. L. Lai, Y. C. Tyan, M. C. Chou, L. C. Wang, M. H. Yang, C. K. Liu, “Angiotensin-converting enzyme gene and plasma protein level in Alzheimer’s disease in Taiwanese.” Age and Ageing, 40, 238-242, 2011. (Impact factor: 3.131, Ranking: Geriatrics & gerontology, 11/40, 27.5%)
4. Y. C. Tyan*, M. H. Yang, T. W. Chung, W. C. Chen, M. C. Wang, Y. L. Chen, S. L. Huang, Y. F. Huang, S. B. Jong, “Characterization of surface modification on self-assembled monolayer-based piezoelectric crystal immunosensor for the quantification of serum -fetoprotein.” Journal of Materials Science: Materials in Medicine, 22, 1383-1391, 2011. (SCI, IF=2.325, Rank=20/70, ENGINEERING, BIOMEDICAL)
5. T. W. Chung, T. Limpanichpakdee, M. H. Yang, Y. C. Tyan, “An electrode of quartz crystal microbalance (QCM) decorated with CNT/chitosan/ fibronectin (FN) for investigating early adhesion and deforming morphology of rat mesenchymal stem cells (rMSCs).” Carbohydrate Polymers, 85(4), 726-732, 2011. (SCI, IF=3.463, Rank=11/79, POLYMER SCIENCE)
6. M. H. Yang, Y. C. Tyan*, Y. F. Huang, S. B. Jong, T. W. Chung, “Quartz crystal microbalance in clinical application.” Biosensors for Health, Environment and Biosecurity / Book 2, ISBN 978-953-307-443-6, Chapter 11, 257-272.
7. M. H. Yang, R. R. Krishnamoorthy, S. B. Jong, P. Y. Chu, Y. H. Yang, W. C. Chen, S. C. J. Chen, A. Dibas, T. Yorio, T. W. Chung, Y. C. Tyan*, “Protein profiling of human non-pigmented ciliary epithelium cell secretome – the differentiation factors characterization for retinal ganglion cell-line.” Journal of Biomedicine and Biotechnology, 2011, 1-28, 2011. (SCI, IF=1.23, Rank=111/160, BIOTECHNOLOGY & APPLIED MICROBIOLOGY)
8. M. H Yang, P. Y. Chu, S. C. J. Chen, T. W. Chung, W. C. Chen, L. B. Tan, W. C. Kan, H. Y. Wang, S. B. Su, Y. C. Tyan*, “Characterization of ADAM28 as a biomarker of bladder transitional cell carcinoma by urinary proteome analysis.” Biochemical and Biophysical Research Communications, 411, 714-720, 2011. (SCI, IF=2.595, Rank=38/73, BIOPHYSICS)
9. Y. C. Tyan*, M. H. Yang, S. C. J. Chen, S. B. Jong, W. C. Chen, Y. H. Yang, T. W. Chung, P. C. Liao, “Characterization of urinary proteome from Blackfoot disease endemic areas - The over-expression of ADAM28 in bladder transitional cell carcinomas.” Rapid Communications in Mass Spectrometry, 25, 2851-2862, 2011. (SCI, IF=2.846, Rank=19/73, CHEMISTRY, ANALYTICAL )
10. L. B. Tan, K. T. Chen, Y. C. Tyan, P. C. Liao, H. R. Guo, “Identification of urine PLK2 as a marker of bladder tumors by proteomic analysis.” World Journal of Urology, 28, 117-122, 2010. (Impact factor: 2.699, Ranking: UROLOGY & NEPHROLOGY 18/57, 32%)
11. J. C. Wang, C. L. Ko, C. C. Hung, Y. C. Tyan, C. H. Lai, W. C. Chen*, C. K. Wang, “Deriving fast setting properties of tetracalcium phosphate/dicalcium phosphate anhydrous bone cement with nanocrystallites on the reactant surfaces.” Journal of Dentistry, 38, 158-165, 2010. (Impact factor: 2.033, Ranking: Dentistry, oral surgery & medicine, 12/55, 21.8%)
12. T. W. Chung, Y. C. Tyan, J. D. Yang, “PCP copolymers arafted with RGD enhance the rates of RGD-PCP micelles internalized into cells.” Journal of Microencapsulation, 27, 514-520, 2010. (Impact factor: 1.890, Ranking: Engineering, chemical, 31/128, 24.2%)
13. L. Peng, E. A. Kapp, D. Fenyö, M.S. Kwon, P. Jiang, S. Wu, Y. Jiang, M. I. Aguilar, N. Ahmed, M. S. Baker, Z. Cai, Y. J. Chen, P. V. Chi, M. C. M. Chung, F. He, A. C. L. Len, P. C. Liao, K. Nakamura, S. M. Ngai, Y. K. Paik, T. L. Pan, T. C. W. Poon, G. H. Salekdeh, R. J. Simpson, R. Sirdeshmukh, C. Srisomsap, J. Svasti, Y. C. Tyan, F. S. Dreyer, D. McLauchlan, P. Rawson, T. W. Jordan, “The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterization of the carbonate-washed membrane standard.” Proteomics, 10, 4142-4148, 2010. (Impact factor: 4.426, Ranking: Biochemical research methods, 11/67, 16.4%)
14. Y. C. Tyan, H. C. Wu, K. T. Liu, H. I. Tsai, T. L. Tsai, M. H. Yang, S. B. Jong, “Determination of Technetium-99 in environmental samples by flow injection-ICP-MS.” Chemistry, 68, 225-233, 2010.
15. H. Y. Wang, L. H. Lo, Y. C. Tyan, H. C. Chen, M. H. Yang, T. Y. Chen, H.Y. J. Wang, J. Shiea, “The study of the distribution of melamine in rat renal tissues by imaging mass spectrometry.” Anal. Methods, 2, 1974-1981, 2010. (Impact factor: 1.036, Ranking: FOOD SCIENCE & TECHNOLOGY, 61/128, 47.6%)
16. Y. S. Lu, P. W. Chiang, T. Y. Liu, Y.L. Chen, M. H. Yang, P. C. Liao, Y. F. Huang, S. B. Jong, Y. C. Tyan*, “Using isotope dilution combined with matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference method for the radioimmunoassay of 3,5,3’-triiodothyronine.” Annals of Nuclear Medicine and Science, 23, 189-194, 2010.
17. P. C. Liao, Y. C. Tyan*, C. Y. Wang, J. F. Hsu, T. C. Chou, H. Y. Lin, “Assessing the binding selectivity of molecularly imprinted polymer artificial antibodies by mass spectrometry-based profiling system.” Journal of Biomedical Materials Research- Part A, 91, 597-604, 2009. (Impact factor: 3.044, Ranking: Engineering, biomedical, 12/70, 17%)
18. T. W. Chung, S. Y. Lin, D. Z. Liu, Y. C. Tyan, J. S. Yang, “Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network.” International Journal of Pharmaceutics, 382, 39-44, 2009. (Impact factor: 3.061, Ranking: Pharmacy and Pharmacology, 66/216, 30%)
19. Y. C. Tyan*, M. H. Yang, S. B. Jong, C. K. Wang, J. T. Shiea, “Melamine contamination.” Analytical and Bioanalytical Chemistry, 395, 729-735, 2009. (Impact factor: 3.841, Ranking: Chemistry, analytical, 9/73, 12%)
20. S. B. Jong, S. L. Huang, C. S. Lin, M. H. Yang, Y. L. Chen, Y. F. Huang, J. T. Shiea, M. C. Wang, Y. C. Tyan*, “Evaluation the effectiveness of 125I anti-AFP monoclonal antibody on QCM utilizing radioactive measurement” Chemistry, 67, 299-307, 2009.
21. M. H. Yang, L. H. Lo, Y. H. Chen, J. T. Shiea, P. C. Wu, Y. C. Tyan, Y. J. Jong, “The study of human neutrophil peptides in saliva by matrix-assisted laser desorption ionization/time-of-flight mass spectrometry.” Rapid Communications in Mass Spectrometry, 23, 3220-3226, 2009. (Impact factor: 2.772, Ranking: Chemistry, analytical, 16/70, 22.8%)
22. S. K. Wang, C. H. Hu, M. C. Lu, C. Y. Duh, P. C. Liao, Y. C. Tyan, “Novel virus-associated proteins encoded by UL112-113 of human cytomegalovirus.” J Gen Virol., 90, 2840-2848, 2009. (Impact factor: 3.092, Ranking: Biotechnology & applied microbiology, 34/144, 23.6%)
23. S. L. Huang, C. S. Lin, Y. S. Lu, S. B. Jong, M. H. Yang, H. Y. Chang, H. Y. Hsun, Y. C. Tyan*, “α-fetoprotein analysis in human serum through quartz crystal microbalance.” IFMBE Proceedings, 25, 116-119, 2009. (EI, DOI: 10.1007/978-3-642-03887-7_32)
24. Y. W. Liu, M. H. Yang, Y. C. Tyan*, P. Y. Liu, P. C. Liao, C. H. Lee, “Proteomic Analysis of Pericardial Effusion: Characteristics of Tuberculosis-Related Proteins.” Proteomics Clin. Appl. 2, 458-466, 2008. (Impact factor: 1.514, Ranking: Biochemical research methods, 49/65, 75%)
25. L. B. Tan, K. T. Chen, Y. C. Tyan, P. C. Liao, H. R.Guo*, “Proteomic analysis for human urinary proteins associated with arsenic intoxication.” Proteomics Clin. Appl. 2, 1087-1098, 2008. (Impact factor: 1.514, Ranking: Biochemical research methods, 49/65, 75%)
26. P. P. Lin, M. H. Yang, P. C. Liao, H. Y. Wu, Louis W. Chang, H. T. Tsai, Y. C. Tyan*, “Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells.” Biochemical and Biophysical Research Communications. 376, 519-524, 2008. (Impact factor: 2.749, Ranking: Biochemistry & molecular biology, 124/263, 47%)
27. Y. C. Tyan*, M. H. Yang, P. C. Liao, J.D. Liao, S. B. Jong, C. Y. Liu, M. C. Wang, M. Grunze, “MALDI-TOF MS sample preparation by using alkanethiolate self-assembled monolyers: A preliminary application for protein sample cleanup and analysis.” International Journal of Mass Spectrometry, 262, 67-72, 2007. (Impact factor: 2.337, Ranking: SPECTROSCOPY, 10/39, 25.6%)
28. M. H. Yang, Y.C. Tyan*, S. B. Jong, Y. F. Huang, P. C. Liao, M. C. Wang, “Identification of human hepatocellular carcinoma-related proteins by proteomic approaches.” Anal. Bioanal. Chem., 388, 637-643, 2007. (Impact factor: 3.841, Ranking: Chemistry, analytical, 9/73, 12%)
29. Y. C. Tyan, P. C. Liao*, “Proteomics analysis of serous fluids and effusions:Pleural, pericardial, and peritoneal.” Proteomics Clin. Appl. 1(8) 834-844, 2007. (Impact factor: 1.514, Ranking: Biochemical research methods, 49/65, 75%)
30. H. S. Wen, L. F. Tsai, C. W. Liu*, Y. C. Tyan, S. L. Shy, B. T. Dai, P. C. Liao, C. Y. Wang, “Effects of iron-cored carbonballs as matrix on matrix-assisted laser desorption ionization-time of flight mass spectrometer analysis.” Japanese Journal of Applied Physics, 46(9B), 6415-6418, 2007. (Impact factor: 1.096, Ranking: Physics, Applied, 41/83, 49%)
31. H. S. Wen, L. F. Tsai, C. W. Liu, Y. C. Tyan, S. L. Shy, B. T. Dai, P. C. Liao, “Investigation of Effects Attributed to Spherical Carbon Nanomaterials in Proteomic Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer.” IEEE, 1015-1017, 2007.
32. J. D. Liao, S. P. Lin, Y. C. Tyan*, C. C. Chen, S. H. Wang, “Immobilized Chitosan onto Polypropylene Non-Woven Fibric for Anti-bacterial and Biomedical Application.” Journal of Materials Science and Engineering. 38(3): 121-128, 2006.
33. Y. C. Tyan, H. R. Guo, C. Y. Liu, P. C. Liao*, “Proteomic profiling of human urinary proteome using nano-high performance liquid chromatography/electrospray ionization tandem mass spectrometry.” Analytica Chimica Acta. 579 (2): 158-176, 2006. (Impact factor: 2.760, Ranking: CHEMISTRY, ANALYTICAL, 11/70, 16%)
34. J. Y. Wu, M. N. Ho, Y. C. Tyan, P. C. Liao*, “Proteomics analysis of bronchoalveolar lavage fluids.” Chemistry, 64(4), 469-476, 2006.
35. Y. C. Tyan*, J. D. Liao, S. B. Jong, P. C. Liao, M. H. Yang, Y. W. Chang, R. Klauser, M. Himmelhaus, M. Grunze, “Characterization of trypsin immobilized on the functionable alkylthiolate self-assembled monolayers: A preliminary application for trypsin digestion chip on protein identification using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.” Journal of Materials Science: Materials in Medicine.16 (2), 135-142, 2005. (Impact factor: 1.248, Ranking: ENGINEERING, BIOMEDICAL, 23/41, 56%)
36. Y. C. Tyan, H. Y. Wu, W. C. Su, P. W. Chen, P. C. Liao*, “Proteomic analysis of human pleural effusion.” Proteomics. 5, 1062-1074, 2005. (Impact factor: 6.088, Ranking: BIOCHEMICAL RESEARCH METHODS, 5/53, 9%)
37. Y. C. Tyan*, S. B. Jong, J. D. Liao, P. C. Liao, M. H. Yang, C.Y. Liu, R. Klauser, M. Himmelhaus, M. Grunze, “Proteomic profiling of erythrocyte proteins by proteolytic digestion chip and identification using two-dimensional electrospray ionization tandem mass spectrometry.” Journal of Proteome Research. 4 (3), 748-757, 2005. (Impact factor: 6.901, Ranking: BIOCHEMICAL RESEARCH METHODS, 2/53, 4%)
38. Y. C. Tyan, H. Y. Wu, W. W. Lai, W. C. Su, P. C. Liao*, “Proteomic profiling of human pleural effusion using two-dimensional nano liquid chromatography tandem mass spectrometry.” Journal of Proteome Research. 4 (4), 1274-1286, 2005. (Impact factor: 6.901, Ranking: BIOCHEMICAL RESEARCH METHODS, 2/53, 4%)
39. M. H. Yang, J. D. Liao, S. B. Jong, P. C. Liao, C. Y. Liu, M. C. Wang, M. Grunze, Y. C. Tyan*, “Identification of human plasma proteins by trypsin immobilized digestion chip and electrospray ionization tandem mass spectrometry.” Journal of Medical and Biological Engineering. 25(2): 81-86, 2005. (Impact factor: 0.42, Ranking: ENGINEERING, BIOMEDICAL, 63/70, 90%)
40. L. C. Lin, Y. C. Tyan, T. S. Shih, Y. C. Chang, P. C. Liao*, “Development and validation of an isotope-dilution electrospray ionization tandem mass spectrometry method with an on-line sample clean-up device for the quantitative analysis of the benzene exposure biomarker S-phenylmercapturic acid in human urine.” Rapid communications in mass spectrometry. 18, 1310-1316, 2004. (Impact factor: 3.087, Ranking: CHEMISTRY, ANALYTICAL, 8/70, 11%)
41. Y. C. Tyan*, J. D. Liao, S. B. Jong, P. C. Liao, M. H. Yang, Y. W. Chang, R. Klauser, M. Himmelhaus, M. Grunze, “Proteomic profiling of platelet proteins by trypsin immobilized self-assembled monolayers digestion chip and protein identification using electrospray ionization tandem mass spectrometry.” Journal of Biomedical Materials Research. 71A, 90-97, 2004. (Impact factor: 2.743, Ranking: ENGINEERING, BIOMEDICAL, 5/41, 12%)
42. Y. C. Tyan*, J. D. Liao, S. P. Lin, C. C. Chen, “The study of sterilization effect by gamma ray irradiation onto the immobilized collagen polypropylene non-woven fabric surfaces.” Journal of Biomedical Materials Research. 67A (3), 1033-1043, 2003. (Impact factor: 2.743, Ranking: ENGINEERING, BIOMEDICAL, 5/41, 12%)
43. Y. C. Tyan*, J. D. Liao, S. P. Lin, ”Surface properties and in vitro analyses of immobilized chitosan onto polypropylene non-woven fabric surface using antenna-coupling microwave plasma.“ Journal of Materials Science: Materials in Medicine. 14, 775-781, 2003. (Impact factor: 1.248, Ranking: ENGINEERING, BIOMEDICAL, 23/41, 56%)
44. Y. C. Tyan, C. W. Hung, P. C. Liao*, “Introduction to ion trap and quadrupole / time-of-flight tandem mass spectrometers and their applications in proteomics research.” Instruments Today. 135, 42-55, 2003.
45. Y. C. Tyan, J. D. Liao*, R. Kauser, I. D. Wu, C. C. Weng, "Assessment and characterization of degradation effect for the varied degree of ultra-violet radiation onto the collagen-bonded polypropylene non-woven fabric surface." Biomaterials. 23(1), 65-76, 2002. (Impact factor: 4.698, Ranking: ENGINEERING, BIOMEDICAL, 2/41, 5%)
46. T. W. Chung*, Y. C. Tyan, J. H. Hsieh, S. S. Wang, S. S. Chu, "Shear stress induced aggregation of oxidized platelets." Thrombosis Research. 105(4), 325-329, 2002. (Impact factor: 2.012, Ranking: HEMATOLOGY, 30/60, 50%)
47. J. D. Liao*, Y. C. Tyan, ”Bioactive assessment and bacteria test for the varied degrees of ultra-violet radiation onto the collagen-immobilized polypropylene non-woven fabric.” Journal of Biomedical Engineering–Applications, Basis & Communications. 14 (1), 20-30, 2002. (EI)
48. Y. C. Tyan, J. D. Liao*, Y. D. Wu, R. Klauser, “Anticoagulant activity of immobilized heparin depending upon the pH of processing environment.” Journal of Biomaterials Applications. 17(2), 153-178, October 2002. (Impact factor: 1.116, Ranking: ENGINEERING, BIOMEDICAL, 27/41, 66%)
49. Y. C. Tyan, J. D. Liao*, Y. D. Wu, K. Y. Hsu, “Study of immobilized heparin in varied pH values onto porous non-woven fabric surface.” Chinese Journal of Medical and Biological Engineering. Vol 20, Iss 1, pp25-30, March 2000.
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中級組員:許幼青
 
分機:2322
 
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