LU face

 

研發長Provost):

 鄭添祿 講座教授Prof. Tain-Lu CHENG

 

聯絡方式:

 電話 (Tel)886-7-312-1101 分機2138

 傳真 (FAX)886-7-322-3170

 E-mail:  tlcheng@kmu.edu.tw

 807高雄市十全一路100號勵學大樓三樓研究發展處

 No.100,Shih-Chuan 1st Road, Kaohsiung 807, Taiwan

 

現任:

     高雄醫學大學研究發展處 研發長 (2018/8~)

     高雄醫學大學生命科學院 院長 (2018/8~)

    高雄醫學大學生物醫學暨環境生物學系 講座教授(2018/8~)

     高雄醫學大學生物標記暨生技藥物中心 主任 (2014/8~)

 

 學歷:

      國防醫學院&中央研究院 生命科學所 博士 (1995~1999)

     國防醫學院 微免所 碩士 (1991~1993)

     高雄醫學院 醫學技術學系 學士 (1987~1991)

 

  經歷:

  高雄醫學大學 醫學研究所 所長 (2014/9~2018/7)

  高雄醫學大學 醫學院 副院長 (2015/08~2018/7)

  高雄醫學大學 生物醫學暨環境生物學系 特聘教授 (2015/08~2018/7)

  高雄醫學大學 產學營運處 產學處長 (2013/3~2014/07)

  高雄醫學大學 產學推動中心主任 (2011/8~2013/2)

  高雄醫學大學 生物醫學暨環境生物學系 系主任 (2009/08~2011/08)

  高雄醫學大學 生命科學院研發組 組長 (2007/08~2009/07)

  高雄醫學大學 生物醫學暨環境生物學系副教授 (2005/08~2008/07)

  高雄醫學大學 生命科學院 院務發展組 組長 (2006/08~2007/07)

  高雄醫學大學 創新生物醫學育成中心 經理 (2007/08~2008/07)

  高雄醫學大學 創新生物醫學育成中心 培育組組長 (2006/08~2007/07)

  高雄醫學大學 基因體醫學研究中心 組長 (2002/08~2006/07)

  高雄醫學大學 生命科學院總務組 組長 (2003/08~2004/07)

  高雄醫學大學 生物醫學暨環境生物學系 助理教授 (2001/08~2005/07)

 

研究專長:

  前驅抗體藥物、電腦&抗體基因工程(人類化抗體)、蛋白質/抗體/雙功能標靶藥物、功能性分子造 影、腫瘤免疫學

 

獲獎:

       1.2008 Outstanding Research Award (RPI award), Kaohsiung Medical University (2008高醫研究傑出教 師獎) 2008 Outstanding Industrial Collaboration Award, Kaohsiung Medical University (2008高醫產學傑出績優獎) 2008 annual excellent technique transfer award, Kaohsiung Medical University (2008高醫傑出技轉獎)

      2.2009 Outstanding Industrial Collaboration Award, Kaohsiung Medical University (2009產學合作--傑出貢獻獎) 2009 annual excellent technique transfer award, Kaohsiung Medical University (2009技術移轉--傑出貢獻獎) 2009 Outstanding Alumni Award of Excellent Paper, Kaohsiung Medical University (2009高醫校友優秀教師論文獎) 2009 annual excellent patent award,Kaohsiung Medical University (2009專利獲證--傑出貢獻獎) 2009 annual excellent research project funding,Kaohsiung Medical University (2009研究傑出教師研究計畫經費最佳獎) 2009 Outstanding Research Award (IF>5), Kaohsiung Medical University (2009研究傑出教師傑出論文獎) 2009 Outstanding Research Award (RPI award), Kaohsiung Medical University. (2009研究傑出教師--最佳研究貢獻獎)

    3.2010 Outstanding Alumni Award of Excellent Paper, Kaohsiung Medical University (2010高醫校友優秀教師論文獎) 2010 annual excellent research project funding, Kaohsiung Medical University (2010研究傑出教師研究計畫經費最佳獎) 2010 Outstanding Research Award (IF>5), Kaohsiung Medical University (2010研究傑出教師傑出論文獎) 2010 Outstanding Research Award, Kaohsiung Medical University. (2010研究傑出教師--最佳研究貢獻獎) 2010 annual excellent technique transfer award, Kaohsiung Medical University (2010技術移轉績優)

    4.2011 Outstanding Alumni Award of Excellent Paper, Kaohsiung Medical University(2011高醫校友優秀教師論文獎) 2011 annual excellent research project funding, Kaohsiung Medical University (2011研究績優教師研究計畫經費績優獎) 2011 annual excellent technique transfer award, Kaohsiung Medical University (2011技術移轉傑出貢獻獎)

     5.2012 Outstanding Alumni Award of Excellent Paper, Kaohsiung Medical University(2012高醫校友優秀教師論文獎) 2012 Outstanding Research Award (IF>5), Kaohsiung Medical University (2012研究傑出教師傑出論文獎) 2012 annual excellent research project funding, Kaohsiung Medical University (2012研究績優教師研究計畫經費績優獎) 2012 annual excellent patent award,Kaohsiung Medical University (2012專利獲證--傑出貢獻獎) 2012 annual excellent technique transfer award, Kaohsiung Medical University (2012技術移轉 卓越獎) 2012 Outstanding Industrial Collaboration Award, Kaohsiung Medical University (2012高醫產學合作卓越獎)

     6.2013 annual excellent research project funding, Kaohsiung Medical University (2013 高雄醫學大學 研究績優教師 研究計畫績優獎)2013 Award of Excellent Paper, Kaohsiung Medical University (2013 高雄醫學大學102學年度 研究論文獎)2013 annual excellent technique transfer award, Kaohsiung Medical University 2013 高雄醫學大學102學年度 技術轉移 績優獎、2013 annual excellent patent award,Kaohsiung Medical University (2013 高雄醫學大學102學年度 專利獲證 優良獎)The Second Prize of the 10th National Innovation Award- Student Research Contest by the Institute for Biotechnology and Medicine Industry. 2013 第十屆國家新創獎『學生組』第二名、The Third Prize of the 10th National Innovation Award- Student Research Contest by the Institute for Biotechnology and Medicine Industry.(2013 第十屆國家新創獎『學生組』第三名)2013榮獲國科會創新到創業競賽計畫(FITI)創業潛力獎累積獎金93萬元

    7. 2014 Ministry of Science and Technology, Outstanding Research Award(科技部傑出研究獎), 2014,The Third Prize of 9th 戰國策Entrepreneurial Competition (2014年第九屆戰國策創業競賽創業組第三名)

2014,The award of the 11th National Innovation Award in the Academic Research Category by the Institute for Biotechnology and Medicine Industry. (2014年第十一屆國家新創獎學研創新獎)

2014 高雄醫學大學 研究績優教師 研究計畫績優獎;

2014 高雄醫學大學103學年度 研究論文獎;

2014高雄醫學大學 技術移轉特別卓越獎 Top Technology Transfer Award (技轉金額 1,000 萬以上);

2014高雄醫學大學 專利獲證優良獎

     8.2015, The award of the 12th National Innovation Award in the Academic Research Category by the Institute for Biotechnology and Medicine Industry. (2015年第十二屆國家新創獎學研創新獎);

2015年第十屆全國戰國策創業競賽創業組第三名;

2015年第十屆全國戰國策創業競賽創業組第二名;

2015高雄醫學大學技術移轉特別卓越獎 Top Technology Transfer Award (技轉金額 1,000 萬以上);

2015高雄醫學大學產學合作卓越獎(產學合作金額 200 萬以上);

2015高雄醫學大學 專利獲證優良獎Award of Patent Approval

     9.2016年第十三屆國家新創獎榮獲學研新創獎;

2016高雄醫學大學第20學術研究類傑出校友

2016高雄醫學大學 優秀論文獎;

2016高雄醫學大學技術移轉特別卓越獎 Top Technology Transfer Award (技轉金額 1,000 萬以上);

2016高雄醫學大學 專利獲證績優獎 Excellence in Patent Approval Award

    10.2017 Ministry of Science and Technology, Outstanding Research Award (科技部傑出研究獎)

 

期刊論文著作:

     選擇性著作(近五年內選擇性著作10篇)

 

  1. Kuo-Hsiang Chuang, Hsin-Ell Wang, Ta-Chun Cheng, Shey-CherngTzou, Chiu-Min Cheng, Chien-Han Kao, Chih-Hung Chuang3, Wei-Lung Tseng, Wen-Chun Hung, Ming-Hong Tai, Tien-Kuei Chang, Bing-Mae Chen, Steve R. Roffler and Tian-Lu Cheng*. Development of anUniversalAnti-Polyethylene Glycol Reporter Gene for Noninvasive Imaging of PEGylated Probes. Journal of Nuclear Medicine,2010, 51:933-941. 2012 IF: Kuo-Hsiang Chuang, Hsin-Ell Wang, Ta-Chun Cheng, Shey-CherngTzou, Chiu-Min Cheng, Chien-Han Kao, Chih-Hung Chuang3, Wei-Lung Tseng, Wen-Chun Hung, Ming-Hong Tai, Tien-Kuei Chang, Bing-Mae Chen, Steve R. Roffler and Tian-Lu Cheng*. Development of anUniversalAnti-Polyethylene Glycol Reporter Gene for Noninvasive Imaging of PEGylated Probes. Journal of Nuclear Medicine,2010, 51:933-941. 2012 IF: 5.774 (6/120, 5%) in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
  2. Kuo-Hsiang Chuang, Shey-CherngTzou, Ya-Chen Chang,Chien-Han Kao, Kuang-Wen, Liao, Ta-Chun Cheng, Bo-Jyun Huang, Chang-Jer Wu, Wei-Lung Tseng, JentaieShiea, Pei-Yu Chu, Steve Roffler, Tian-Lu Cheng* Measurement of Free Polyethylene Glycolby a Novel Cell-Based Anti-Polyethylene Glycol ELISA. Anal Chem. 2010 Mar 15;82(6):2355-62. 2012 IF: 5.695 (3/75, 4%) in CHEMISTRY, ANALYTICAL
  3. Cheng TL, Chuang KH, Chen BM, Roffler SR. Analytical Measurement of PEGylated Molecules. Bioconjug Chem. 2012 Feb 2.23, 8818992012 IF=4.580 (8/55=14.5%) in CHEMISTRY, ORGANIC
  4.  Kuo-Hsiang Chuang, Hsin-Ell Wang, Fang-Ming Chen, Shey-CherngTzou, Chiu-Min Cheng, Ya-Chen Chang, Wei-Lung Tseng, JentaieShiea, Shiu-Ru Lin, Jaw-Yuan Wang, Bing-Mae Chen, Steve R. Roffler andTian-Lu Cheng*. Endocytosis of PEGylated agents enhances cancer imaging and anti-cancer efficacy. Molecular cancer therapeutics, 2010, 9(6);1903-1912. 2012 IF=5.599 (29/197=14.72%) in ONCOLOGY
  5. CH Chuang, KH Chuang, HE Wang, SR Roffler, SC Tzou, TC Cheng, CH Kao, SY Wu, WL Tseng, J Shiea, JM Wang* and TL Cheng*. In vivo PET Imaging of protease activity by hydrophilic-to-hydrophobic conversion of a protease substrate.Clin Cancer Res. 2012 Jan 1;18(1):238-247.2012 IF=7.837 (12/196=6.1%) in ONCOLOGY
  6. Cheng TC, Chuang KH, Chen M, Wang HE, Tzou SC, Su YC, Chuang CH, Kao CH, Chen BM, Chang LS, Roffler SR, Cheng TL*. Sensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length.Bioconjug Chem. 2013 Jul 9. [Epub ahead of print]2012 IF=4.580(8/55=14.5%) in CHEMISTRY, ORGANIC
  7. Su YC, Chen BM, Chuang KH, Tian-Lu Cheng*,Roffler SR. Sensitive Quantification of PEGylated Compounds by Second-Generation Anti-Poly(ethylene glycol) Monoclonal Antibodies.Bioconjug Chem. 2010 Jul 21;21(7):1264-70.2012IF=4.580(8/55=14.5%) in CHEMISTRY, ORGANIC
  8. Ta-Chun Cheng, Steve R. Roffler, Shey-CherngTzou, Kuo-Hsiang Chuang, Yu-Cheng Su, Chih-Hung Chuang, Chien-Han Kao,Chien-Shu Chen,I-Hong Harn, Kuan-Yi Liu,Tian-Lu Cheng*and Yu-Ling Leu*.An Activity-Based Infrared Glucuronide Trapping Probe for Imaging b-Glucuronidase Expression in Deep Tissues.J. Am. Chem. Soc. 2012, 134, 31033110.2012 IF=10.677 (11/152=7.2%) in CHEMISTRY, MULTIDISCIPLINARY
  9. Shey-CherngTzou, Steve Roffler, Kuo-Hsiang Chuang, Hsin-Pei Yeh, Chien-Han Kao, Yu-Cheng Su, Chiu-Min Cheng, Wei-Lung Tseng, JentaieShiea, Kai-Wen Cheng, Bing-Mae Chen, Tian-Lu Cheng*and Hsin-Ell Wang. Micro-PET imaging of b-glucuronidase activity by the hydrophobic conversion of a glucuronide probe. Radiology, 2009, Sep;252(3):754-62. 2012 IF=6.339 (2/120=1.67%) in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
  10. Tian-Lu Cheng and Steve Roffler. Membrane-tethered proteins for basic research, imaging and therapy. Medicinal Research Reviews, 2008, Nov;28(6):885-928. 2012 IF= 9.583 (5/261=1.9 %) in PHARMACOLOGY & PHARMACY

       2008~2014 Publications

  2014 publications

  1. Cheng CM, Tzou SC, Zhuang YH, Huang CC, Kao CH, Liao KW, Cheng TC, Chuang CH, Hsieh YC, Tai MH, Cheng TL*. Functional production of a soluble and secreted single-chain antibody by a bacterial secretion system. PLoS One. 2014 May 13;9(5):e97367
  2. Chen YJ, Lin HC, Chen KC, Lin SR, Cheng TL, Chang LS. Taiwan cobra phospholipase A<sub>2</sub> suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells. Toxicon. 2014 May 27;86C:79-88.
  3. Su YC, Al-Qaisi TS, Tung HY, Cheng TL, Chuang KH, Chen BM, Roffler SR. Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies. MAbs. 2014 May 14;6(4).
  4. Chuang CH, Wang WJ, Li CF, Ko CY, Chou YH, Chuu CP, Cheng TL*, Wang JM*. The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer. Cell Death Dis. 2014 May 8;5:e1220
  5. Chen YJ, Wu SC, Chen CY, Tzou SC, Cheng TL, Huang YF, Yuan SS, Wang YM. Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection. Biomaterials. 2014 Jan;35(1):304-15.

2013 publications

  1. Cheng TC, Chuang KH, Chen M, Wang HE, Tzou SC, Su YC, Chuang CH, Kao CH, Chen BM, Chang LS, Roffler SR, Cheng TL*. Sensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length. Bioconjug Chem. 2013 Aug 5. [Epub ahead of print]
  2. Liu WH, Chen YJ, Cheng TL, Lin SR, Chang LS. Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit α and MAPK phosphatase-1 expression in human leukemia U937 cells. Cell Signal. 2013 Sep;25(9):1845-51
  3. Chen SH, Kuo YT, Cheng TL, Chen CY, Chiu YY, Lai JJ, Chang CC, Jaw TS, Wang YM, Liu GC. In vivo magnetic resonance imaging of mice liver tumors using a new gadolinium-based contrast agent. Kaohsiung J Med Sci. 2013 May;29(5):246-53.
  4. Cheng CM, Chen FM, Lu YL, Tzou SC, Wang JY, Kao CH, Liao KW, Cheng TC, Chuang CH, Chen BM, Roffler S, Cheng TL*. Expression of β-glucuronidase on the surface of bacteria enhances activation of glucuronide prodrugs. Cancer Gene Ther. 2013 May;20(5):276-81
  5. Wu SC, Lin KL, Wang TP, Tzou SC, Singh G, Chen MH, Cheng TL, Chen CY, Liu GC, Lee TW, Hu SH, Wang YM. Imaging specificity of MR-optical imaging agents following the masking of surface charge by poly(ethylene glycol). Biomaterials. 2013 May;34(16):4118-27.
  6. Lu CY, Tsai HL, Uen YH, Hu HM, Chen CW, Cheng TL, Lin SR, Wang JY. Circulating tumor cells as a surrogate marker for determining clinical outcome to mFOLFOX chemotherapy in patients with stage III colon cancer. Br J Cancer. 2013 Mar 5;108(4):791-7.

2012 publications

  1. Chen SH, Kuo YT, Singh G, Cheng TL, Su YZ, Wang TP, Chiu YY, Lai JJ, Chang CC, Jaw TS, Tzou SC, Liu GC, Wang YM. Development of a Gd(III)-Based Receptor-Induced Magnetization Enhancement (RIME) Contrast Agent for β-Glucuronidase Activity Profiling. Inorg Chem. 2012 Nov 1. [Epub ahead of print] 2011 IF=4.601, (4/44=9%) in CHEMISTRY, INORGANIC & NUCLEAR
  2. Lin YJ, Liu YS, Yeh HH, Cheng TL, Wang LF. Self-assembled poly(ε-caprolactone)-g-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells. Int J Nanomedicine. 2012;7:4169-83. 2011 IF=3.130, (70/261=26.8%) in PHARMACOLOGY & PHARMACY
  3. Chen CH, Liu YK, Lin YL, Chuang HY, Hsu WT, Chiu YH, Cheng TL, Liao KW.A rapid and convenient method to enhance transgenic expression in target cells. Prep Biochem Biotechnol. 2012;42(5):448-61. 2011 IF=0.466, (279/290=96.2%) in BIOCHEMISTRY & MOLECULAR BIOLOGY
  4. Kao CH, Cheng CM, Chuang KH, Chuang CH, Tzou SC, Cheng TC, Hsieh YC, Liao KW, Wang YM, Chang LS, Roffler SR, Chen FM, Cheng TL*. A regularly spaced and self-revealing protein ladder for anti-tag Western blot analysis. Anal Biochem. 2012 Dec 1;431(1):1-3. 2011 IF=2.996 (19/73=26%) in CHEMISTRY, ANALYTICAL
  5. Chen CP, Hsieh YT, Prijovich ZM, Chuang HY, Chen KC, Lu WC, Tseng Q, Leu YL, Cheng TL, Roffler SR. ECSTASY, an adjustable membrane-tethered/soluble protein expression system for the directed evolution of mammalian proteins. Protein Eng Des Sel. 2012 25(7):367-75. 2011 IF=2.937, (47/160=29.3%) in Biotechnology & Applied Microbiology
  6. Cheng TL, Chuang KH, Chen BM, Roffler SR. Analytical Measurement of PEGylated Molecules. Bioconjug Chem. 2012 Feb 2. 23, 881899. 2011 IF: 4.930 (8/56=14.2%) CHEMISTRY, ORGANIC
  7. Ta-Chun Cheng, Steve R. Roffler, Shey-Cherng Tzou, Kuo-Hsiang Chuang, Yu-Cheng Su, Chih-Hung Chuang, Chien-Han Kao, Chien-Shu Chen,I-Hong Harn, Kuan-Yi Liu, Tian-Lu Cheng* and Yu-Ling Leu*. An Activity-Based Infrared Glucuronide Trapping Probe for Imaging b-Glucuronidase Expression in Deep Tissues. J. Am. Chem. Soc. 2012, 134, 31033110. 2011 IF=9.907, (11/154=7.1%) in CHEMISTRY, MULTIDISCIPLINARY
  8. CH Chuang, KH Chuang, HE Wang, SR Roffler, SC Tzou, TC Cheng, CH Kao, SY Wu, WL Tseng, J Shiea, JM Wang* and TL Cheng*. In vivo PET Imaging of protease activity by hydrophilic-to-hydrophobic conversion of a protease substrate. Clin Cancer Res. 2012 Jan 1;18(1):238-247. 2011 IF=7.742, (14/196=7.1%) in ONCOLOGY
  9. Chen CH, Lin YL, Liu YK, He PJ, Lin CM, Chiu YH, Wu CJ, Cheng TL, Liu SJ, Liao KW. Liposome-based polymer complex as a novel adjuvant: enhancement of specific antibody production and isotype switch. Int J Nanomedicine. 2012;7:607-21. Epub 2012 Feb 3.
  10. Huang MY, Wang HM, Tok TS, Chang HJ, Chang MS, Cheng TL, Wang JY, Lin SR. EVI2B, ATP2A2, S100B, TM4SF3, and OLFM4 As Potential Prognostic Markers for Postoperative Taiwanese Colorectal Cancer Patients. DNA Cell Biol. 2012 Apr;31(4):625-35.

2011 publications

  1. Kasala D, Lin TS, Chen CY, Liu GC, Kao CL, Cheng TL, Wang YM. [Gd(Try-TTDA)(H2O)]2-: a new MRI contrast agent for copper ion sensing. Dalton Trans. 2011 May 14;40(18):5018-25.
  2. Tseng FJ, Liu YK, Chung YS, Lin YL, Chen CH, Wang WY, Chen YC, Tsai NM, Cheng TL, Pan RY, Hu TM, Lee RP, Liao KW A fusion protein composed of receptor binding domain of vascular endothelial growth factor-A and constant region fragment of antibody: angiogenesis antagonistic activity. Cytotechnology. 2011 May;63(3):285-93.
  3. Chen KC, Wu SY, Leu YL, Prijovich ZM, Chen BM, Wang HE, Cheng TL, Roffler SR. A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment. Bioconjug Chem. 2011 May 18;22(5):938-48.
  4. Huang PT, Chen KC, Prijovich ZM, Cheng TL, Leu YL, Roffler SR.Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of β-glucuronidase in tumors. Cancer Gene Ther. 2011 Jun;18(6):381-9.
  5. Liu YK, Lin YL, Chen CH, Lin CM, Ma KL, Chou FH, Tsai JS, Lin HY, Chen FR, Cheng TL, Chang CC, Liao KW A unique and potent protein binding nature of liposome containing polyethylenimine and polyethylene glycol: a nondisplaceable property. Biotechnol Bioeng. 2011 Jun;108(6):1318-27

2010 publications

  1. Kuo-Hsiang Chuang, Hsin-Ell Wang, Ta-Chun Cheng, Shey-Cherng Tzou, Chiu-Min Cheng, Chien-Han Kao, Chih-Hung Chuang3, Wei-Lung Tseng, Wen-Chun Hung, Ming-Hong Tai, Tien-Kuei Chang, Bing-Mae Chen, Steve R. Roffler and Tian-Lu Cheng*. Development of an Universal Anti-Polyethylene Glycol Reporter Gene for Noninvasive Imaging of PEGylated Probes. Journal of Nuclear Medicine, 2010, 51:933-941
  2. 2009IF: 6.424 (1/104 0.96%) RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
  3. Kuo-Hsiang Chuang, Shey-Cherng Tzou, Ya-Chen Chang, Chien-Han Kao, Kuang-Wen, Liao, Ta-Chun Cheng, Bo-Jyun Huang, Chang-Jer Wu, Wei-Lung Tseng, Jentaie Shiea, Pei-Yu Chu, Steve Roffler, Tian-Lu Cheng* Measurement of Free Polyethylene Glycol by a Novel Cell-Based Anti-Polyethylene Glycol ELISA. Anal Chem. 2010 Mar 15;82(6):2355-62. 2009IF: 5.214 (3/70 4.29%) CHEMISTRY, ANALYTICAL
  4. Kuo-Hsiang Chuang, Hsin-Ell Wang, Fang-Ming Chen, Shey-Cherng Tzou, Chiu-Min Cheng, Ya-Chen Chang, Wei-Lung Tseng, Jentaie Shiea, Shiu-Ru Lin, Jaw-Yuan Wang, Bing-Mae Chen, Steve R. Roffler and Tian-Lu Cheng*. Endocytosis of PEGylated agents enhances cancer imaging and anti-cancer efficacy. Molecular cancer therapeutics, 2010, 9(6);1903-1912 2009IF: 4.953 (27/165 16.36%) ONCOLOGY
  5. Tsao DA, Chang HJ, Lin CY, Hsiung SK, Huang SE, Ho SY, Chang MS, Chiu HH, Chen YF, Tian-Lu Cheng*, Shiu-Ru L. Gene expression profiles for predicting the efficacy of the anticancer drug 5-fluorouracil in breast cancer. DNA Cell Biol. 2010 Jun;29(6):285-93. 2009IF: 2.280  (170/283 60.07%) BIOCHEMISTRY & MOLECULAR BIOLOGY
  6. Su YC, Chen BM, Chuang KH, Tian-Lu Cheng*, Roffler SR. Sensitive Quantification of PEGylated Compounds by Second-Generation Anti-Poly(ethylene glycol) Monoclonal Antibodies. Bioconjug Chem. 2010 Jul 21;21(7):1264-70. 2009IF: 4.305 (7/57 12.28%) CHEMISTRY, ORGANIC
  7. Chung FY, Cheng TL, Chang HJ, Chiu HH, Huang MY, Chang MS, Chen CC, Yang MJ, Wang JY, Lin SR. Differential gene expression profile of MAGE family in taiwanese patients with colorectal cancer. J Surg Oncol. 2010 Aug 1;102(2):148-53. 2009IF: 2.502 (37/166 22.29%) SURGERY
  8. Yu CJ, Lin CY, Liu CH, Cheng TL, Tseng WL. Synthesis of poly(diallyldimethylammonium chloride)-coated Fe(3)O(4) nanoparticles for colorimetric sensing of glucose and selective extraction of thiol. Biosens Bioelectron. 2010 Oct 15;26(2):913-7.. 2009IF: 5.429 (2/70 2.86%) CHEMISTRY, ANALYTICAL
  9. Yang Yu Hsiang, Yung-Hsin Wang, Jaw-Yuan Wang, Fang-Ming Chen, Wei-Lung Tseng, Che-Hsin Lin, Ming-Chia Hsieh, Ming-Yii Huang, Shiu-Ru Lin and Tian-Lu Cheng*. Simultaneous detection of multiple single nucleotide polymorphisms by a simple SNP chip. Genet Test Mol Biomarkers. 2010 Oct;14(5):653-9. 2009 IF1.17 (119/14681.5) GENETICS & HEREDITY
  10. Li YC, Chen BM, Wu PC, Cheng TL, Kao LS, Tao MH, Lieber A, Roffler SR. Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling.. J Immunol. 2010 Jun 1;184 (11):5959-63.
  11. 2009IF: 5.646 (18/128 14.06%) IMMUNOLOGY
  12. Lin CS, He PJ, Tsai NM, Li CH, Yang SC, Hsu WT, Wu MS, Wu CJ, Cheng TL, Liao KW. A potential role for Helicobacter pylori heat shock protein 60 in gastric tumorigenesis. Biochem Biophys Res Commun. 2010 Feb 5;392(2):183-9. 2009IF: 2.548 (146/283 51.59%) BIOCHEMISTRY & MOLECULAR BIOLOGY
  13. Lin LF, Chuang CH, Li CF, Liao CC, Cheng CP, Cheng TL, Shen MR, Tseng JT, Chang WC, Lee WH, Wang JM. ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. Cancer Res. 2010 Jan 1;70(1):192-201. 2009IF: 7.543  (13/16 7.88%) ONCOLOGY

2009 publications

  1. Shey-Cherng Tzou, Steve Roffler, Kuo-Hsiang Chuang, Hsin-Pei Yeh, Chien-Han Kao, Yu-Cheng Su, Chiu-Min Cheng, Wei-Lung Tseng, Jentaie Shiea, Kai-Wen Cheng, Bing-Mae Chen, Tian-Lu Cheng*and Hsin-Ell Wang. Micro-PET imaging of b-glucuronidase activity by the hydrophobic conversion of a glucuronide probe. Radiology, 2009, Sep;252(3):754-62
  2. 2009IF: 6.341  (2/104 1.92%) RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
  3. Chiu-Min Cheng, Pei-Yu Chu, Kuo-Hsiang Chuang, Steve R. Roffler, Chien-Han Kao, Wei-Lung Tseng, Jentaie Shiea, Wen-Da Chang, Yu-Cheng Su, Bing-Mae Chen, Yun-Ming Wang and Tian-Lu Cheng*. Hapten-derivatized nanoparticle targeting and imaging of gene expression by multimodality imaging systems. Cancer gene therapy, 2009 Jan;16(1):83-90. (2009IF: 3.126   (41/150 27.33%) BIOTECHNOLOGY & APPLIED MICROBIOLOGY
  4. Chen YM, Cheng TL, Tseng WL. Fluorescence turn-on detection of iodide, iodate and total iodine using fluorescein-5-isothiocyanate-modified gold nanoparticles. Analyst. 2009 Oct;134(10):2106-12. 2009IF: 3.272  (11/70 15.71%) CHEMISTRY, ANALYTICAL
  5. Li MD, Tseng WL, Cheng TL. Ultrasensitive detection of indoleamines by combination of nanoparticle-based extraction with capillary electrophoresis/laser-induced native fluorescence J Chromatogr A. 2009 Sep 4;1216(36):6451-8. 2009 IF: 4.101  (4/70 8.5%) CHEMISTRY, ANALYTICAL
  6. Yu CJ, Cheng TL, Tseng WL. Effects of Mn2+ on oligonucleotide-gold nanoparticle hybrids for colorimetric sensing of Hg2+: improving colorimetric sensitivity and accelerating color change. Biosens Bioelectron. 2009 Sep 15;25(1):204-10. 2009IF:5.429 (2/70 2.86%)CHEMISTRY, ANALYTICAL
  7. Chung FY, Huang MY, Yeh CS, Chang HJ, Cheng TL, Yen LC, Wang JY, Lin SR. GLUT1 gene is a potential hypoxic marker in colorectal cancer patients. BMC Cancer. 2009 Jul 20;9:241. 2009 IF: 2.736 (71/165 43.03%) ONCOLOGY
  8. Liu GS, Huang HT, Lin CJ, Shi JY, Liu LF, Tseng RT, Weng WT, Lam HC, Wen ZH, Cheng TL, Hsu KS, Tai MH. Prophylactic Proopiomelanocortin Expression Alleviates Capsaicin-Induced Neurogenic Inflammation in Rat Trachea. Shock. 2009 Dec;32(6):645-50.2008IF: 2.871  (23/166 13.86%) SURGERY
  9. Cheng SC, Cheng TL, Chang HC, Shiea J. Using laser-induced acoustic desorption/electrospray ionization mass spectrometry to characterize small organic and large biological compounds in the solid state and in solution under ambient conditions. Anal Chem. 2009 Feb 1;81(3):868-74. 2009IF: 5.214 (3/70 4.29%) CHEMISTRY, ANALYTICAL
  10. Li MD, Cheng TL, Tseng WL. Nonionic surfactant-capped gold nanoparticles for selective enrichment of aminothiols prior to CE with UV absorption detection. Electrophoresis. 2009 Jan;30(2):388-95. 2009IF: 3.077 (13/70 18.57%) CHEMISTRY, ANALYTICAL
  11. Chen TJ, Cheng TH, Chen CY, Hsu SC, Cheng TL, Liu GC, Wang YM. Targeted Herceptin-dextran iron oxide nanoparticles for noninvasive imaging of HER2/neu receptors using MRI. J Biol Inorg Chem. 2009 Feb;14(2):253-60. 2009IF: 3.415 (8/44 18.189%) CHEMISTRY, INORGANIC & NUCLEAR

2008 Publications

  1. Tian-Lu Cheng and Steve Roffler. Membrane-tethered proteins for basic research, imaging and therapy. Medicinal Research Reviews, 2008, Nov;28(6):885-928 2009IF: 8.656  (8/236 3.39%) PHARMACOLOGY & PHARMACY
  2. Chiu-Min Cheng, Yu-Ling Lu , Kuo-Hsiang Chuang,Wen-Chun Hung, Jentaie Shiea, Yu-Cheng Su, Chien-Han Kao, Bing-Mae Chen, Steve Roffler and Tian-Lu Cheng* Tumor-targeting prodrug-activating bacteria for cancer therapy. Cancer Gene Ther. 2008, Jun;15(6):393-401. 2009IF: 3.126   (41/150 27.33%) BIOTECHNOLOGY & APPLIED MICROBIOLOGY
  3. Cheng CY, Yuan CH, Cheng SC, Huang MZ, Chang HC, Cheng TL, Yeh CS, Shiea J. Electrospray-assisted laser desorption/ionization mass spectrometry for continuously monitoring the states of ongoing chemical reactions in organic or aqueous solution under ambient conditions. Anal Chem. 2008 Oct 15;80(20):7699-705. 2009IF: 5.214 (3/70 4.29%) CHEMISTRY, ANALYTICAL
  4. Wu HP, Huang CC, Cheng TL, Tseng WL. Sodium hydroxide as pretreatment and fluorosurfactant-capped gold nanoparticles as sensor for the highly selective detection of cysteine. Talanta. 2008 Jul 15;76(2):347-52. 2009IF: 3.290  (9/70 12.86%) CHEMISTRY, ANALYTICAL
  5. Uen YH, Lu CY, Tsai HL, Yu FJ, Huang MY, Cheng TL, Lin SR, Wang JY. Persistent Presence of Postoperative Circulating Tumor Cells is a Poor Prognostic Factor for Patients with Stage I-III Colorectal Cancer after Curative Resection. Ann Surg Oncol. 2008, Aug;15(8):2120-8.
  6. 2009IF: 4.130  (6/166 3.61%)SURGERY
  7. Liu FC, Cheng TL, Shen CC, Tseng WL, Chiang MY. Synthesis of Cysteine-Capped Zn(x)Cd(1)(-)(x)Se alloyed quantum dots emitting in the blue-green spectral range. Langmuir. 2008 Mar 4; 24(5):2162-7. 2009IF:3.898 (25/212 11.79%)MATERIALS SCIENCE, MULTIDISCIPLINARY
  8. Chen YM, Yu CJ, Cheng TL, Tseng WL. Colorimetric detection of lysozyme based on electrostatic interaction with human serum albumin-modified gold nanoparticles. Langmuir. 2008 Apr 1; 24(7):3654-60. 2009IF:3.898 (25/212 11.79%)MATERIALS SCIENCE, MULTIDISCIPLINARY
  9. Huang MY, Wang YH, Chen FM, Lee SC, Fang WY, Cheng TL, Hou MF, Wang JY, Lin SR. Multiple Genetic Polymorphisms of GSTP1 313AG, MDR1 3435CC, and MTHFR 677CC highly correlated with early relapse of breast cancer patients in Taiwan. Ann Surg Oncol. 2008 Mar;15(3):872-80. 2009IF: 4.130  (6/166 3.61%)SURGERY
  10. Huang MY, Fang WY, Lee SC, Cheng TL, Wang JY, Lin SR. ERCC2 2251A>C genetic polymorphism was highly correlated with early relapse in high-risk stage II and stage III colorectal cancer patients: a preliminary study. BMC Cancer. 2008 Feb 12;8:50. 2009IF: 2.736 (71/165 43.03%) ONCOLOGY