評估阿茲海默症患者的工具要使用口語還是非口語記憶測試
評估阿茲海默症患者的工具要使用口語還是非口語記憶測試
這篇研究比較了台灣非失智症和阿茲海默症患者之間所選擇的口語和非口語記憶測試的區分效度。阿茲海默症患者通常在記憶方面出現初始缺陷。記憶測試可以根據使用的刺激的方式分為口語或非口語。
研究中使用故事回憶測試評估語言記憶，使用建構性實踐測試評估非語言記憶。我們比較了所選擇的口語和非口語記憶測試在非失智症和阿茲海默症之間的區分效度。98名輕度阿茲海默症患者和269名非失智症個體參加了故事回憶測試（即時和延遲回憶）以及建構性實踐測試（複製和延遲回憶）。我們使用接收者操作特徵曲線和曲線下面積來進行測試之間的比較。
阿茲海默症患者在所有記憶測試中表現不佳，接收者操作特徵曲線分析顯示，故事回憶的即時和延遲回憶，以及建構性實踐的延遲回憶在區分是否失智，皆具有良好的分類準確度，曲線下面積分別為0.90、0.87和0.87。
這些結果支持口語和非口語記憶測試都是可靠的評估阿茲海默症患者的工具。
應用與亮點：
1.不論是口語和非口語記憶測試對於區分台灣一般人群中的失智症和非失智 症皆有效用
2.臨床上，口語認知測驗最常用於評估記憶力。然而，有時較困難的單字會混淆測量的表現，並可能導致記
憶障礙的結論。因此，應謹慎解釋口語記憶測試結果，並將測試結果與其他形式的測驗結果做綜合評估。
【研究團隊】
團隊成員：李冠瑩、簡靖芳、楊淵韓
代表單位：高雄醫學大學神經科學研究中心及高醫附院和大同醫院神經科
團隊簡介：本團隊致力於研究阿茲海默氏症的相關危險因子及致病機轉
研究聯繫Email：endless@kmu.edu.tw
【論文資訊】
論文出處：Am J Alzheimers Dis Other Demen. 2023 Jan-Dec; 38:15333175231201036
全文下載：https://pubmed.ncbi.nlm.nih.gov/37683179/
The Use of Verbal and Nonverbal Memory Tests for Alzheimer’s Disease Screening in Taiwan Chinese
The Use of Verbal and Nonverbal Memory Tests for Alzheimer's Disease Screening in Taiwan Chinese
Patients with Alzheimer’s disease typically have initial deficits in memory. Memory testing can be categorized as verbal or nonverbal by the modality of the stimuli used. We compared the discriminative validity of selected verbal and nonverbal memory tests between non-dementia and Alzheimer’s disease in Taiwan. 98 patients with mild Alzheimer's disease and 269 non-dementia individuals underwent story recall test (immediate and delayed recall), and constructional praxis test (copy and delayed recall). The receiver-operating characteristic curve and area under the curve were evaluated to compare between tests. Patients with Alzheimer’s disease performed poorly across all memory tests, and the receiver-operating characteristic curve analysis indicated that story recall immediate and relayed recall, and constructional praxis delayed recall had good classification accuracy with area under the curve of .90, .87 and .87 respectively. These results provide support that both verbal and nonverbal memory tests are reliable measure for screening patients with Alzheimer's disease.
Research Team Members: Kuan-Ying Li, Ching-Fang Chien, Yuan-Han Yang
Representative Department: Neuroscience Research Center, Kaohsiung Medical University . Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan.
Introduction of Research Team: The team has been committed to the risk factors and pathogenic mechanisms of Alzheimer's disease.
Contact Email: endless@kmu.edu.tw
Publication: Am J Alzheimers Dis Other Demen. 2023 Jan-Dec; 38:15333175231201036
Full-Text Article: https://pubmed.ncbi.nlm.nih.gov/37683179/
